MitoCarn™ Brain

Of particular importance to brain health is the Acetyl-L-Carnitine form of L-Carnitine in MitoCarn™ Brain. MitoCarn™ Brain is a unique compound that can pass through the blood brain barrier, delivering these health-promoting molecules directly to the brain.*

MitoCarn™ Brain is able to cross from the blood directly into the brain (the blood/brain barrier). It crosses through the OCTN2 transporter. Enzymes then convert the long chain fatty acids to shorter chain Acyl-CoAs. These Acyl-CoAs can cross the inner mitochondrial membrane via a transporter. Another enzyme localized in the inner mitochondrial membrane converts the molecules back to Acyl-CoAs and free L-Carnitine, which then exit the mitochondria.

Thorough clinical research indicates that these molecules may:

  • Improve energy status in the brain*
  • Protect central and peripheral nervous system synapses*
  • Elevate nerve growth factor levels*
  • Decrease oxidative stress, helping to mitigate subsequent cell death*
  • Function as a precursor for acetylcholine*
  • Be incorporated into glutamate, glutamine and GABA*
  • Be incorporated into lipids for myelination and cell growth*
MitoCarn Brain to power up cognition

MitoCarn™ Brain can help power up cognition daily*

The brain uses more ATP than any other organ. In fact, your brain uses 70% of the ATP your entire body creates. Providing your brain with the essential materials it requires to function optimally can help support clarity, focus, and memory. 

MitoCarn™ Brain gets past the blood brain barrier*

MitoCarn™ Brain is an Acetyl-L-Carnitine form, which effectively penetrates the blood/brain barrier, delivering nutrients directly to the brain. These molecules increase healthy blood flow and support wide-ranging cognitive functions, including mitochondrial function, antioxidant functions, and the generation of glutathione.* 

MitoCarn™ Brain performs valuable cleanup* 

The mitochondrial processes required to produce the energy your brain uses every day leave toxic residuals behind. MitoCarn™ Brain helps remove these residual molecules and perform a constant “clean up” function that supports healthy cognition.* 

Supported Delivery Systems for Formulators

MitoCarn™ Brain is highly soluble and can be included in both liquid and solid formulations:

Clinical studies show MitoCarn™ Brain helps with memory and cognitive function*

Hundreds of studies have been conducted on the beneficial impact of the acetylated compound in MitoCarn™ Brain on memory, recall, alertness, and other cognitive performance variables. Studies also showed that MitoCarn™ Brain helps maintain the body’s ability to protect the nervous system tissue from oxidative stress and supports the neurotransmitter activity necessary for positive moods.* You can review a selection of MitoCarn™ Brain health studies here.

MitoCarn™ Brain can pass the blood/brain barrier, making it highly effective for cognitive performance supplements. The Acetyl-L-Carnitine compound of MitoCarn™ Brain supports improved: 

  • Energy output available for cognitive functions*
  • Learning*
  • Recall*
  • Memory*
  • Focus*
  • Healthy blood flow to the brain*
  • Removal of metabolic byproducts from mitochondria*

MitoCarn™ Brain is highly soluble and can be included in both liquid and solid formulations. This unique Acetyl-L-Carnitine compound is guaranteed to be: 

  • BSE/TSE risk free (according to the European Guidelines (EMEA-410/01 rev. 3.))
  • Melamine-free
  • Pesticide-free
  • Allergen-free (according to European Directive 2000/13/EC, Regulation (EU) No. 1169/2011 and latest amendments)
  • Non-GMO
  • Not sterilized or processed with radiation 
  • Not engineered with nanomaterials

Of particular importance to brain health is the Acetyl-L-Carnitine form of L-Carnitine in MitoCarn™ Brain. MitoCarn™ Brain is a unique compound that can pass through the blood brain barrier, delivering these health-promoting molecules directly to the brain. 

MitoCarn™ Brain is able to cross from the blood directly into the brain (the blood/brain barrier). It crosses through the OCTN2 transporter. Enzymes then convert the long chain fatty acids to shorter chain Acyl-CoAs. These Acyl-CoAs can cross the inner mitochondrial membrane via a transporter. Another enzyme localized in the inner mitochondrial membrane converts the molecules back to Acyl-CoAs and free L-Carnitine, which then exit the mitochondria. 

Thorough clinical research indicates that these molecules may: 

  • Improve energy status in the brain*
  • Protect central and peripheral nervous system synapses* 
  • Elevate nerve growth factor levels*
  • Decrease oxidative stress, helping to mitigate subsequent cell death* 
  • Function as a precursor for acetylcholine*
  • Be incorporated into glutamate, glutamine and GABA*
  • Be incorporated into lipids for myelination and cell growth*

Clinical Studies Involving MitoCarn™ Brain on Cognitive Function

Malaguarnea, M., et al., Acetyl-L-Carnitine improves cognitive functions in severe hepatic encephalopathy: A randomized and controlled clinical trial. Metab Brain Dis (26), pp. 281-289. 2011. DOI: 10.1007/s11011-9260-z. Summary: Improvements in 16 areas of cognitive functioning, including attention, learning, and memory, indicate that Acetyl-L-Carnitine is an effective tool in treating severe hepatic encephalopathy. It also protects against ammonia toxicity. Download PDF »

Montgomery, S.A., et al., Meta-analysis of double blind randomized controlled clinical trials of Acetyl-L-L-Carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmaco, Vol. 18, pp. 66-71. Summary: Meta-analysis of 21 studies on mild cognitive impairment (MCI) and/or Mild Alzheimer’s Disease (AD) showed improvements in cognitive function after as few as three months. In addition, cognitive decline in Alzheimer’s patients was delayed. Download PDF »

Nasca, C., et al. L-AcetylL-Carnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. PNAS. doi/10.1073/pnas.1216100110. Summary: Acetyl-L-L-Carnitine supplementation produced rapid, long-lasting antidepressant action in rats due to enhanced brain function. Download PDF »

Nasca, C., et al. Action of Acetyl-L-Carnitine in association with Mianserine on depressed old people. New Trends in Clinical Neuropharmacology, Vol. Ill No. 16233, pp. 225-230. Summary: Patients showed specific effects on the cognitive processes with positive improvement in attention and perception, memory and recall. Download PDF »

Rossini, M., et al. Double-blind, multicenter trial comparing Acetyl-L-L-Carnitine with placebo in the treatment of fibromyalgia patients. Summary: Measured the effectiveness of L-Carnitine in improving metabolic function on patients with fibromyalgia (FMS). Results showed significant improvements in patients’ mental health. Download PDF »

Zanardi, R., Smeraldi, E. A double-blind, randomised, controlled clinical trial of Acetyl-L-Carnitine vs. amisulpride in the treatment of dysthymia. European Neuropsychopharmacology (2006) 16, pp. 281-287. Summary: Comparison of effects of L-Carnitine and an antidepressant drug on dysthymia. Download PDF »



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