the Science behind MItoCarn

Science

Myocardial Clinical Studies with MitoCarn™ Heart

Bigalli, D.P., Lamanna, F., Boem, A., Davini, P., Controlled Study on L-Carnitine Therapeutic Efficacy in Post-Infarction. Drugs Exptl. Clin. Res. XVIII(8) 355-365. 1992. Summary: This 12-month study on 160 patients following myocardial infarction showed that L-Carnitine represents an effective treatment in post-infarction ischaemic cardiopathy. Download PDF »

Casciani, C. U. et al., Beneficial Effects of L-Carnitine in Post-dialysis Syndrome. Current Therapeutic Research, Vol. 32, No. 1. July, 1982. Summary: Dialysis patients have low muscle concentrations of L-Carnitine. This study’s findings suggest that providing muscle cells with free L-Carnitine supported the health of patients undergoing dialysis. Download PDF »

Corbucci, G.C., Lochi, F. L-Carnitine in Cardiogenic Shock Therapy: Pharmacodynamic Aspects and Clinical Data. Int. J. Clin. Pharm. Res. XIII, 2, pp. 87-91. 1993. Summary: L-Carnitine is heavily involved in the production and utilization of ATP energy in myocardial cells. L-Carnitine depletion in these cells correlates with higher rates of Cardiogenic Shock. Download PDF »

Iliceto, S., et al. Effects of L-Carnitine Administration on Left Ventricular Remodeling After Acute Anterior Myocardial Infarction: The L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. JACC Vol. 26, No. 2, pp. 380-387. 1995. Summary: L-Carnitine treatment in the first year after acute myocardial infarction attenuated left ventricular dilation compared to a placebo. Download PDF »

Rizzon, P., et al. High Doses of L-Carnitine in Acute Myocardial Infarction: Metabolic and Antiarrhythmic Effects. European Heart Journal. Vol 10., pp. 502-508. 1989. Summary: Exogenous supplementation of L-Carnitine effectively increased free L-Carnitine in the blood and in the urine. Download PDF »

Tarantini, G., et al., Metabolic Treatment with L-Carnitine in Acute Anterior ST Segment Elevation Myocardial Infarction. Cardiology, Vol. 106, pp. 215-223. 2006. DOI: 10.1159/000093131. Summary: L-Carnitine therapy led to a reduction in early mortality in patients who had previously experienced anterior acute myocardial infarction (AMI). Download PDF »

Winter, S.C., et al. L-Carnitine for Treatment of Cardiomyopathies. Cardiologia. (Suppl 2), pp. 685-686. 1998. Summary: In pediatric patients with compromised myocardial function, L-Carnitine supplementation helped restore metabolism to a more normal state with improvements in strength, muscle tone, and myocardial contractility. Download PDF »


Science

Clinical Studies Involving MitoCarn™ Brain on Cognitive Function

Malaguarnea, M., et al., Acetyl-L-Carnitine improves cognitive functions in severe hepatic encephalopathy: A randomized and controlled clinical trial. Metab Brain Dis (26), pp. 281-289. 2011. DOI: 10.1007/s11011-9260-z. Summary: Improvements in 16 areas of cognitive functioning, including attention, learning, and memory, indicate that Acetyl-L-Carnitine is an effective tool in treating severe hepatic encephalopathy. It also protects against ammonia toxicity. Download PDF »

Montgomery, S.A., et al., Meta-analysis of double blind randomized controlled clinical trials of Acetyl-L-L-Carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmaco, Vol. 18, pp. 66-71. Summary: Meta-analysis of 21 studies on mild cognitive impairment (MCI) and/or Mild Alzheimer’s Disease (AD) showed improvements in cognitive function after as few as three months. In addition, cognitive decline in Alzheimer’s patients was delayed. Download PDF »

Nasca, C., et al. L-AcetylL-Carnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. PNAS. doi/10.1073/pnas.1216100110. Summary: Acetyl-L-L-Carnitine supplementation produced rapid, long-lasting antidepressant action in rats due to enhanced brain function. Download PDF »

Nasca, C., et al. Action of Acetyl-L-Carnitine in association with Mianserine on depressed old people. New Trends in Clinical Neuropharmacology, Vol. Ill No. 16233, pp. 225-230. Summary: Patients showed specific effects on the cognitive processes with positive improvement in attention and perception, memory and recall. Download PDF »

Rossini, M., et al. Double-blind, multicenter trial comparing Acetyl-L-L-Carnitine with placebo in the treatment of fibromyalgia patients. Summary: Measured the effectiveness of L-Carnitine in improving metabolic function on patients with fibromyalgia (FMS). Results showed significant improvements in patients’ mental health. Download PDF »

Zanardi, R., Smeraldi, E. A double-blind, randomised, controlled clinical trial of Acetyl-L-Carnitine vs. amisulpride in the treatment of dysthymia. European Neuropsychopharmacology (2006) 16, pp. 281-287. Summary: Comparison of effects of L-Carnitine and an antidepressant drug on dysthymia. Download PDF »


Science

Clinical Studies with MitoCarn™ Sport on Exercise and Performance

Cherchi, A., et al., Effects of L-Carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo controlled crossover study. Int Jour of Clinical Pharmacology, Therapy and Toxicology, Vol. 23, No. 10, pp. 569-572, 1985. Summary: Supplementation with L-Carnitine increased the total exercise work load and maximum watts to onset of angina. Download PDF »

Loster, et al., Prolonged Oral L-Carnitine Substitution Increases Bicycle Ergometer Performance in Patients with Severe, Ischemically Induced Cardiac Insufficiency. Cardiovascular Drugs and Therapy. 1999. Summary: Prolonged 120-day study with high dosage on the effect of L-Carnitine on exercise performance in patients with advanced cardiac insufficiency. Positive findings indicate a systemic effect of L-Carnitine, including lowered exercise heart rate and systolic pressure and a peripheral effect on skeletal muscle. Download PDF »


Science

Clinical Study with MitoCarn™ Weight on Weight Management

Molfino, A., et al., Caloric Restriction and L-Carnitine Administration Improves Insulin Sensitivity in Patients With Impaired Glucose Metabolism. J Parenteral and Enteral Nutrition Vol 34, No 3, pp. 295-299, 2010. Summary: Researched the role of L-Carnitine on insulin resistance in humans by showing that L-Carnitine administration, in association with a hypocaloric diet, reduces plasma insulin levels and improves insulin resistance in subjects. Download PDF »