Science

Myocardial Clinical Studies with MitoCarn™ Heart

Bigalli, D.P., Lamanna, F., Boem, A., Davini, P., Controlled Study on L-Carnitine Therapeutic Efficacy in Post-Infarction. Drugs Exptl. Clin. Res. XVIII(8) 355-365. 1992. Summary: This 12-month study on 160 patients following myocardial infarction showed that L-Carnitine represents an effective treatment in post-infarction ischaemic cardiopathy. Download PDF »

Casciani, C. U. et al., Beneficial Effects of L-Carnitine in Post-dialysis Syndrome. Current Therapeutic Research, Vol. 32, No. 1. July, 1982. Summary: Dialysis patients have low muscle concentrations of L-Carnitine. This study’s findings suggest that providing muscle cells with free L-Carnitine supported the health of patients undergoing dialysis. Download PDF »

Corbucci, G.C., Lochi, F. L-Carnitine in Cardiogenic Shock Therapy: Pharmacodynamic Aspects and Clinical Data. Int. J. Clin. Pharm. Res. XIII, 2, pp. 87-91. 1993. Summary: L-Carnitine is heavily involved in the production and utilization of ATP energy in myocardial cells. L-Carnitine depletion in these cells correlates with higher rates of Cardiogenic Shock. Download PDF »

Iliceto, S., et al. Effects of L-Carnitine Administration on Left Ventricular Remodeling After Acute Anterior Myocardial Infarction: The L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. JACC Vol. 26, No. 2, pp. 380-387. 1995. Summary: L-Carnitine treatment in the first year after acute myocardial infarction attenuated left ventricular dilation compared to a placebo. Download PDF »

Rizzon, P., et al. High Doses of L-Carnitine in Acute Myocardial Infarction: Metabolic and Antiarrhythmic Effects. European Heart Journal. Vol 10., pp. 502-508. 1989. Summary: Exogenous supplementation of L-Carnitine effectively increased free L-Carnitine in the blood and in the urine. Download PDF »

Tarantini, G., et al., Metabolic Treatment with L-Carnitine in Acute Anterior ST Segment Elevation Myocardial Infarction. Cardiology, Vol. 106, pp. 215-223. 2006. DOI: 10.1159/000093131. Summary: L-Carnitine therapy led to a reduction in early mortality in patients who had previously experienced anterior acute myocardial infarction (AMI). Download PDF »

Winter, S.C., et al. L-Carnitine for Treatment of Cardiomyopathies. Cardiologia. (Suppl 2), pp. 685-686. 1998. Summary: In pediatric patients with compromised myocardial function, L-Carnitine supplementation helped restore metabolism to a more normal state with improvements in strength, muscle tone, and myocardial contractility. Download PDF »